Stabilization of Hypersonic Boundary Layers by Porous Coatings

A second-mode stability analysis has been performed for a hypersonic boundary layer on a wall covered by a porous coating with equally spaced cylindrical blind microholes. Massive reduction of the second mode amplification is found to be due to the disturbance energy absorption by the porous layer. This stabilization effect was demonstrated by experiments recently conducted on a sharp cone in the T-5 high-enthalpy wind tunnel of the Graduate Aeronautical Laboratories of the California Institute of Technology. Their experimental confirmation of the theoretical predictions underscores the possibility that ultrasonically absorptive porous coatings may be exploited for passive laminar flow control on hypersonic vehicle surfaces

Reactant Jetting in Unstable Detonation

We note the common existence of a supersonic jet structure locally embedded within a surrounding transonic flow field in the hitherto unrelated phenomena of unstable gaseous detonation and hypervelocity blunt body shock wave interaction. Extending prior results that demonstrate the consequences of reduced endothermic reaction rate for the supersonic jet fluid in the blunt body case, we provide an explanation for observations of locally reduced OH PLIF signal in images of the keystone reaction zone structure of weakly unstable detonations. Modeling these flow features as exothermically reacting jets with similarly reduced reaction rates, we demonstrate a mechanism for jetting of bulk pockets of unreacted fluid with potentially differing kinetic pathways into the region behind the primary detonation front of strongly unstable mixtures. We examine the impact of mono-atomic and diatomic diluents on transverse structure. The results yield insight into the mechanisms of transition and characteristic features of both weakly and strongly unstable mixtures

Experiments on Passive Hypervelocity Boundary-Layer Control Using an Ultrasonically Absorptive Surface

Recently performed linear stability analyses suggested that transition could be delayed in hypersonic boundary layers by using an ultrasonically absorptive surface to damp the second mode (Mack mode). Boundary-layer transition experiments were performed on a sharp 5.06-deg half-angle round cone at zero angle of attack in the T5 Hypervelocity Shock Tunnel to test this concept. The cone was constructed with a smooth surface around half the cone circumference (to serve as a control) and an acoustically absorptive porous surface on the other half. Test gases investigated included nitrogen and carbon dioxide at M∞ ≃ 5 with specific reservoir enthalpy ranging from 1.3 to 13.0 MJ/kg and reservoir pressure ranging from 9.0 to 50.0 MPa. Comparisons were performed to ensure that previous results obtained in similar experiments (on a regular smooth surface) were reproduced, and the results were extended to examine the effects of the porous surface. These experiments indicated that the porous surface was highly effective in delaying transition provided that the pore size was significantly smaller than the viscous length scale

Sparse 3D Point-cloud Map Upsampling and Noise Removal as a vSLAM Post-processing Step: Experimental Evaluation

The monocular vision-based simultaneous localization and mapping (vSLAM) is one of the most challenging problem in mobile robotics and computer vision. In this work we study the post-processing techniques applied to sparse 3D point-cloud maps, obtained by feature-based vSLAM algorithms. Map post-processing is split into 2 major steps: 1) noise and outlier removal and 2) upsampling. We evaluate different combinations of known algorithms for outlier removing and upsampling on datasets of real indoor and outdoor environments and identify the most promising combination. We further use it to convert a point-cloud map, obtained by the real UAV performing indoor flight to 3D voxel grid (octo-map) potentially suitable for path planning.Comment: 10 pages, 4 figures, camera-ready version of paper for "The 3rd International Conference on Interactive Collaborative Robotics (ICR 2018)

Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling

Tumor necrosis factor (TNF) has various effects on phosphorylation-mediated cellular signaling. Combining phosphoproteomics, subcellular localization analyses and kinase inhibitor assays, the authors provide systems level insights into TNF signaling and identify modulators of TNF-induced cell death. Tumor necrosis factor (TNF) is one of the few cytokines successfully targeted by therapies against inflammatory diseases. However, blocking this well studied and pleiotropic ligand can cause dramatic side-effects. Here, we reason that a systems-level proteomic analysis of TNF signaling could dissect its diverse functions and offer a base for developing more targeted therapies. Therefore, we combine phosphoproteomics time course experiments with subcellular localization and kinase inhibitor analysis to identify functional modules of protein phosphorylation. The majority of regulated phosphorylation events can be assigned to an upstream kinase by inhibiting master kinases. Spatial proteomics reveals phosphorylation-dependent translocations of hundreds of proteins upon TNF stimulation. Phosphoproteome analysis of TNF-induced apoptosis and necroptosis uncovers a key role for transcriptional cyclin-dependent kinase activity to promote cytokine production and prevent excessive cell death downstream of the TNF signaling receptor. This resource of TNF-induced pathways and sites can be explored at

Evidence for a dynamical ground state in the frustrated pyrohafnate Tb2Hf2O7

We report the physical properties of Tb2Hf2O7 based on ac magnetic susceptibility \chi_ac(T), dc magnetic susceptibility \chi(T), isothermal magnetization M(H), and heat capacity C_p(T) measurements combined with muon spin relaxation (\muSR) and neutron powder diffraction measurements. No evidence for long-range magnetic order is found down to 0.1 K. However, \chi_ac(T) data present a frequency-dependent broad peak (near 0.9 K at 16 Hz) indicating slow spin dynamics. The slow spin dynamics is further evidenced from the \muSR data (characterized by a stretched exponential behavior) which show persistent spin fluctuations down to 0.3 K. The neutron powder diffraction data collected at 0.1 K show a broad peak of magnetic origin (diffuse scattering) but no magnetic Bragg peaks. The analysis of the diffuse scattering data reveals a dominant antiferromagnetic interaction in agreement with the negative Weiss temperature. The absence of long-range magnetic order and the presence of slow spin dynamics and persistent spin fluctuations together reflect a dynamical ground state in Tb2Hf2O7.Comment: 11 pages and 8 figure

Structural changes of laminar separation bubbles induced by global linear instability

The topology of the composite flow fields reconstructed by linear superposition of a two-dimensional boundary layer flow with an embedded laminar separation bubble and its leading three-dimensional global eigenmodes has been studied. According to critical point theory, the basic flow is structurally unstable; it is shown that in the presence of three-dimensional disturbances the degenerate basic flow topology is replaced by a fully three-dimensional pattern, regardless of the amplitude of the superposed linear perturbations. Attention has been focused on the leading stationary eigenmode of the laminar separation bubble discovered by Theofilis; the composite flow fields have been fully characterized with respect to the generation and evolution of their critical points. The stationary global mode is shown to give rise to a three-dimensional flow field which is equivalent to the classical U-shaped separation, defined by Hornung & Perry, and induces topologies on the surface streamlines that are resemblant to the characteristic stall cells observed experimentally

Carbon Dioxide Injection for Hypervelocity Boundary Layer Stability

An approach for introducing carbon dioxide as a means or stabilizing a hypervelocity boundary layer over a slender bodied vehicle is investigated through the use of numerical simulations. In the current study, two different test bodies are examined. The first is a five-degree-half-angle cone currently under research at the GALCIT T5 Shock Tunnel with a 4 cm porous wall insert used to transpire gas into the boundary layer. The second test body is a similar cone with a porous wall over a majority of cone surface. Computationally, the transpiration is performed using an axi-symmetric flow simulation with wall-normal blowing. The effect of the injection and the transition location are gauged by solving the parabolized stability equations and using the semi-empirical e^N method. The results show transition due to the injection for the first test body and a delay in the transition location for the second test body as compared to a cone without injection under the same flight conditions. The mechanism for the stabilizing effect of carbon dioxide is also explored through selectively applying non-equilibrium processes to the stability analysis. The results show that vibrational non-equilibrium plays a role in reducing disturbance amplification; however, other factors also contribute

Gut microbiota and colonization resistance against bacterial enteric infection

The gut microbiome is critical in providing resistance against colonization by exogenous microorganisms. The mechanisms via which the gut microbiota provide colonization resistance (CR) have not been fully elucidated, but they include secretion of antimicrobial products, nutrient competition, support of gut barrier integrity, and bacteriophage deployment. However, bacterial enteric infections are an important cause of disease globally, indicating that microbiota-mediated CR can be disturbed and become ineffective. Changes in microbiota composition, and potential subsequent disruption of CR, can be caused by various drugs, such as antibiotics, proton pump inhibitors, antidiabetics, and antipsychotics, thereby providing opportunities for exogenous pathogens to colonize the gut and ultimately cause infection. In addition, the most prevalent bacterial enteropathogens, including Clostridioides diflicile, Salmonella enterica serovar Typhimurium, enterohemorrhagic Escherichia coli, Shigella flexneri, Campylobacter jejuni, Vibrio cholerae, Yersinia enterocolitica, and Listeria monocytogenes, can employ a wide array of mechanisms to overcome colonization resistance. This review aims to summarize current knowledge on how the gut microbiota can mediate colonization resistance against bacterial enteric infection and on how bacterial enteropathogens can overcome this resistance.Molecular basis of bacterial pathogenesis, virulence factors and antibiotic resistanc

Design and Characterization of a Hypervelocity Expansion Tube Facility

We report on the design and characterization of a 152 mm diameter expansion tube capable of accessing a range of high enthalpy test conditions with Mach numbers up to 7.1 for aerodynamic studies. Expansion tubes have the potential to offer a wide range of test flow conditions as gas acceleration is achieved through interaction with an unsteady expansion wave rather than expansion through a fixed area ratio nozzle. However, the range of test flow conditions is in practice limited by a number of considerations such as short test time and large amplitude flow disturbances. We present a generalized design strategy for small-scale expansion tubes. As a starting point, ideal gas dynamic calculations for optimal facility design to maximize test time at a given Mach number test condition are presented, together with a correction for the expansion head reflection through a non-simple region. A compilation of practical limitations that have been identified for expansion tube facilities such as diaphragm rupture and flow disturbance minimization is then used to map out a functional design parameter space. Experimentally, a range of test conditions have been verified through pitot pressure measurements and analysis of schlieren images of flow over simple geometries. To date there has been good agreement between theoretical and experimental results